Arthritis in Type 2 Diabetes Mellitus Reda

Objectives: Estimating the possible causes of arthropathies in patients with type 2 diabetes mellitus attending outpatient clinics of internal medicine department at Menoufia university hospital. Background: Diabetes mellitus (DM) is a chronic disease and has become one of the main threats to human health in recent decades. Diabetes worldwide was estimated at between 151 million and 171 million in the year 2000 and, it is estimated that this number will triple by 2050. Uncontrolled diabetes with increased blood glucose is strongly correlated to causing long-term microvascular and macrovascular complications, such as nephropathy, neuropathy, retinopathy, muscular dystrophy and atherosclerosis. Rheumatological diseases are now common, which have an increased prevalence in diabetic population. Patients &Methods: The study include 90 patients,Patients divided into 3 groups group 1:30 patients with type 2 diabetes mellitus without arthropathy, group 2: 30 patients with type 2 diabetes mellitus with arthropathy and group 3: 30 patients not diabetics with arthropathy. All the patients were subjected to the following: History taking with general, rheumatological and neurological clinical examinations, The following laboratory tests were done for all the patient: Randum blood sugar, Glycated hemoglobin(HbA1c),Erythrocyte sedimentation rate (ESR), Rheumatoid factor (RF) in the serum, using the latex fixation test, Serum uric acid and Anti-nuclear antibody(ANA), also plain x-ray of affected joint were done for patients with arthropathy. Results: BMI was significantly higher among diabetic patients with arthropathy (33.64± 2.26Regarding RBS, it was significantly higher among diabetic patients with arthropathy (288.10± 83.64). and diabetic patients without arthropathy (240.53± 51.37), Regarding HbA1C, it was significantly higher among diabetic patients with arthropathy (8.72± 1.09) and diabetic patients without arthropathy (7.39± 0.47) Regarding ESR, it was significantly higher among non diabetic patients (58.60± 27.29) Regarding serum uric acid, it was significantly higher among non diabetic patients (5.11± 1.18), no significant difference between the studied groups regarding CRP (P>0.05), Regarding RF, it was significantly lower among diabetic patients with arthropathy Regarding ANA, it was significantly lower among patients with arthropathy. Conclusion and Recommendations: Musculoskeletal complications are most commonly seen in patients with a long standing history of type 2diabetes mellitus. Diabetes mellitus is associated with several musculoskeletal disorders. The incidence of diabetes mellitus and the life expectancy of the diabetic patient have both increased, resulting in increased prevalence and clinical importance of musculoskeletal alterations in diabetic subjects. The development of musculoskeletal disorders is dependent on age and the duration of diabetes mellitus. It has been difficult to show a direct correlation with the metabolic control of diabetes mellitus. Most of these disorders can be diagnosed clinically but some radiological examination may help, especially in differential diagnosis. [Reda M Badr, Ahmed A Shoaib, Khaled M El-zorkany and Eman E Hassan. Arthritis in Type 2 Diabetes Mellitus. Nat Sci 2015;13(5):92-98]. (ISSN: 1545-0740). http://www.sciencepub.net/nature. 11